Presenilin 1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A19103-20, A19103-100
Citations, Manuals and SDS Available upon request.
Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Synonyms: AD3; FAD; PS1; PS-1; S182; PSNL1; ACNINV3; Presenilin 1
GeneID: 5663
Swiss-Prot: P49768
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Calculated Molecular Weight: 53kDa
Observed Molecular Weight: 30kDa/46kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Presenilin 1 (P49768).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Cancer, Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Autophagy, ESC Pluripotency and Differentiation, Endocrine Metabolism, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease, Neurodegenerative Diseases Markers
Recommended Dilutions: WB: 1:500 - 1:2000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cell Membrane, Cell surface, Endoplasmic Reticulum Membrane, Golgi Apparatus Membrane, Multi-pass Membrane Protein,
Positive Samples: A-431, Jurkat, U-251MG, Mouse testis, Mouse liver, Mouse brain, Rat brain
Keywords: 5663, sc-1245, sc-1244, sc-7860, AD3, FAD, presenilin 1, Protein S182, PS 1, PS1, PS1 CTF12, PSEN1, PSNL1, S182, Presenilin-1, PS-1, presenilin-1, P49768, Presenilin 1, Presenilin-1 Isoform I-467, Alzheimer Disease 3, EC 3.4.23.-, ACNINV3
Symbol: PSEN1
Category: Monoclonal Antibodies
Research Use Only