Prion Protein Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A8821-20, A8821-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
Synonyms: CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C; Prion Protein
GeneID: 5621
Swiss-Prot: P04156
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 28kDa
Observed Molecular Weight: 30kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 154-253 of human Prion Protein (P04156).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Immunology Inflammation, CDs, Neuroscience, Neurodegenerative Diseases, Stem Cells, Hematopoietic Progenitors
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Mouse brain, Rat brain
Cellular Location: Cell Membrane, Cytoplasm, GPI-anchor, Golgi Apparatus, Lipid-anchor, Nucleus
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.