PRKAR2B Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A19745-20, A19745-100
Citations, Manuals and SDS Available upon request.
Background: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
Synonyms: PRKAR2; RII-BETA; PRKAR2B
GeneID: 5577
Swiss-Prot: P31323
Reactivity: Mouse, Rat
Tested Applications: ELISA, WB, IHC-P
Calculated Molecular Weight: 46kDa
Observed Molecular Weight: 46kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 319-418 of human PRKAR2B (P31323).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Signal Transduction, G protein signaling, G-Protein-Coupled Receptors Signaling to MAPK Erk, Kinase, MAPK-Erk Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Mitochondrial Control of Apoptosis, Inhibition of Apoptosis, Cytoskeleton, Actins, Endocrine Metabolism, Lipid Metabolism, Insulin Receptor Signaling Pathway, Neuroscience, Neurodegenerative Diseases, Dopamine Signaling in Parkinson's Disease
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Cell Membrane
Positive Samples: Mouse brian, Rat brain
Keywords: PRKAR2B, PRKAR2, RII-BETA, protein kinase cAMP-dependent type II regulatory subunit beta, cAMP-dependent protein kinase type II-beta regulatory subunit|H_RG363E19.2|WUGSC:H_RG363E19.2|cAMP-dependent protein kinase type II-beta regulatory chain|protein kinase, cAMP-dependent, regulatory subunit type II beta|protein kinase, regulatory, type II, beta, P31323
Symbol: PRKAR2B
Category: Monoclonal Antibodies
Research Use Only