RAB8A Monoclonal Antibody
Catalogue Numbers: MB67039-50, MB67039-100
Sizes: 50µl, 100µl
Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Swiss-Prot: P61006
Host: Mouse
Reactivity: Human, Mouse
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: The Rab8 GTPase is a member of the Ras superfamily that functions in protein transport and membrane restructuring . Studies show that Rab8 is localized to the trans Golgi network (TGN), basolateral membrane, and vesicular structures where it helps regulate target protein transport between TGN and the basolateral membrane . Overexpression studies and mutation analysis of Rab8 and its associated Rab8GEF indicate additional roles in actin and microtubule remodeling during polarized membrane transport and membrane protrusion formation . Rab8 associates with myosin Vb and is required for translocation of GLUT4 following insulin stimulation in muscle . Control of target protein vesicle transport by Rab8 also regulates MT1-MMP activity during extracellular matrix formation and JRAB/MICAL-L2 at tight junction formation .
Purification and Purity: This antibody is purified through a protein G column.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of RAB8A protein.
Extra Notes: Western blot analysis of RAB8A expression in Hela (A), HCT116 (B) whole cell lysates.
Bioworld Molecular Weight: ~ 23 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: MEL; RAB8; Ras-related protein Rab-8A; Oncogene c-mel
Immunogen: Recombinant fusion protein of human RAB8A. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified