Rad50 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A3869-20, A3869-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
Synonyms: NBSLD; RAD502; hRad50; Rad50
GeneID: 10111
Swiss-Prot: Q92878
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 154kDa
Observed Molecular Weight: 154kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1200-1300 of human Rad50 (Q92878).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Epigenetics Nuclear Signaling, DNA Damage Repair, ATM Signaling Pathway, Cell Biology Developmental Biology, Cell Cycle, Cell Cycle Control-G2 M DNA Damage Checkpoint
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, K-562, U-87MG, Mouse testis, Rat testis
Cellular Location: Chromosome, Nucleus, Telomere
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.