Rad51 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A2829-20, A2829-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms: RECA; BRCC5; FANCR; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930; Rad51
GeneID: 5888
Swiss-Prot: Q06609
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 37kDa
Observed Molecular Weight: 37kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Rad51 (Q06609).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, ChIP
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | ChIP: 5μg antibody for 10μg-15μg of Chromatin
Research Areas: Epigenetics Nuclear Signaling, DNA Damage Repair, ATM Signaling Pathway, Cell Biology Developmental Biology, Cell Cycle, Cell Cycle Control-G2 M DNA Damage Checkpoint
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, MCF7, Mouse testis, Rat testis
Cellular Location: Cytoplasm, Mitochondrion Matrix, Nucleus, Centrosome, Cytoskeleton, Microtubule Organizing Center, Perinuclear Region
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.