Ran Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A4374-20, A4374-100
Citations, Manuals and SDS Available upon request.
Background: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
Synonyms: TC4; Gsp1; ARA24; Ran
GeneID: 5901
Swiss-Prot: P62826
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 24kDa
Observed Molecular Weight: 24kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 117-216 of human Ran (P62826).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Epigenetics Nuclear Signaling, RNA Binding, Nuclear Receptor Signaling, Signal Transduction, G protein signaling, Small G proteins, Cell Biology Developmental Biology, Cell Cycle, Centrosome
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, 293T, Mouse brain, Mouse spleen, Mouse thymus, Rat testis
Cellular Location: Cytoplasm, Melanosome, Nucleus, Nucleus envelope
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.