Recombinant IKB alpha Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-81430-50, E-AB-81430-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: IKB alpha
Target Synonym: I kappa B alpha; I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; IKBA; IKBalpha; MAD 3; MAD3; NF kappa B inhibitor alpha; NFKBI; IKB alpha
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Immunology, Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Rat
Application: WB
Isotype: IgG
Clonality: Rabbit Monoclonal
Clone No.: R06-9E9
UNIProt ID: P25963
Background: Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA, synonyms: IKBA, MAD-3, NFKBI). NFKB1 or NFKB2 is bound to REL, RELA , or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime.
Concentration: 300 μg/mL
Immunogen: A synthetic peptide of human IKB alpha
Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification Method: Affinity Purified
Dilution: WB 1;1000-1:2000
Calculated MW: 36kDa
Observed MW: 39kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only