Recombinant Ubiquitin K63 Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-81618-50, E-AB-81618-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: Ubiquitin K63
Target Synonym: UBB; UBB; Ubiquitin
Research Areas: Cell Biology
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human
Application: WB, IHC-P, IF
Isotype: IgG
Clonality: Rabbit Monoclonal
Clone No.: R06-2H7
UNIProt ID: P0CG47
Background: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
Concentration: 300 μg/mL
Immunogen: A synthetic peptide of human Ubiquitin (linkage-specific K63)
Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification Method: Affinity Purified
Dilution: WB 1:500-1:1000 IHC 1:50-1:100 IF 1:50-1:100
Calculated MW: 8kDa
Observed MW: 8kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only