Ret Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A20845-20, A20845-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.
Synonyms: PTC; MTC1; HSCR1; MEN2A; MEN2B; CDHF12; CDHR16; RET-ELE1; Ret
GeneID: 5979
Swiss-Prot: P07949
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IF/ICC
Calculated Molecular Weight: 124kDa
Observed Molecular Weight: 150kDa/175kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human Ret (NP_066124.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Protein phosphorylation, Cancer, Signal Transduction, Kinase, Tyrosine kinases, Cell Biology Developmental Biology, Growth factors
Recommended Dilutions: WB: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cell Membrane, Endosome Membrane, Single-pass Type I Membrane Protein
Positive Samples: SH-SY5Y, Neuro-2a, Rat brain
Keywords: 5979, sc-1290, sc-13104, sc-167, RET, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51, ret proto-oncogene, proto-oncogene tyrosine-protein kinase receptor Ret, CUX1/RET fusion, RET receptor tyrosine kinase, RET transforming sequence, cadherin family member 12, cadherin-related family member 16, hydroxyaryl-protein kinase, proto-oncogene c-Ret, rearranged during transfection, receptor tyrosine kinase, ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease), P07949, Ret Proto-Oncogene, Cadherin-Related Family Member 16, Rearranged During Transfection, RET Receptor Tyrosine Kinase, Cadherin Family Member 12, Proto-Oncogene C-Ret, Ret Proto-Oncogene (Multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 1, Hirschsprung Disease), Multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 1, Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret, Hirschsprung Disease 1, EC 2.7.10.1, Ret, RETELE1, RET ELE1, sc1290, sc 1290, sc13104, sc 13104, sc167, sc 167
Symbol: RET
Category: Monoclonal Antibodies
Research Use Only