RNF20 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A4784-20, A4784-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).
Synonyms: BRE1; BRE1A; hBRE1; RNF20
GeneID: 56254
Swiss-Prot: Q5VTR2
Reactivity: Human, Mouse
Calculated Molecular Weight: 114kDa
Observed Molecular Weight: 80kDa/120kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RNF20 (Q5VTR2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones, Cell Biology Developmental Biology, Ubiquitin
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, 293T, C2C12, Mouse testis
Cellular Location: Nucleus
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.