ROCK1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A11158-20, A11158-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.
Synonyms: ROCK-I; P160ROCK; ROCK1
GeneID: 6093
Swiss Prot: Q13464
Tested Applications: ELISA, WB
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 158kDa
Observed Molecular Weight: 158kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1100-1200 of human ROCK1 (Q13464).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Cancer, Signal Transduction, G protein signaling, Kinase, Serine threonine kinases, Cell Biology Developmental Biology, Apoptosis, Cell Cycle, Centrosome, Cell Adhesion, Cytoskeleton, Microfilaments, Microtubules, Actins, Death Receptor Signaling Pathway, TGF-b-Smad Signaling Pathway
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HT-29, Hep G2, Jurkat, C6, Mouse lung
Cellular Location: Cell Membrane, Cell Projection, Cytoplasm, Golgi Apparatus Membrane, Peripheral Membrane Protein, bleb, centriole, Centrosome, Cytoskeleton, lamellipodium, Microtubule Organizing Center, ruffle,
Keywords: 6093, sc-34326, sc-6055, sc-6056, sc-52953, sc-71965, sc-5560, sc-87349, sc-87350, p160 ROCK 1, P160ROCK, PRO0435, ROCK1, ROCK-I, Rho associated coiled-coil containing protein kinase 1, rho-associated protein kinase 1, p160 ROCK-1, renal carcinoma antigen NY-REN-35, Q13464, Rho Associated Coiled-Coil Containing Protein Kinase 1, Renal Carcinoma Antigen NY-REN-35, P160 ROCK-1, Rho-Associated, Coiled-Coil-Containing Protein Kinase 1, Coiled-Coil-Containing Protein Kinase I, Rho-Associated Protein Kinase 1, EC 2.7.11.1, ROCKI, ROCK I, sc34326, sc 34326, sc6055, sc 6055, sc6056, sc 6056, sc52953, sc 52953, sc71965, sc 71965, sc5560, sc 5560, sc87349, sc 87349, sc87350, sc 87350, TGF-β, TGF-beta, TGF-b, TGF β, TGF beta, TGF b, Smad, WNT, β-Catenin, b-Catenin, bate-Catenin, β Catenin, b Catenin, bate Catenin
Symbol: ROCK1
Category: Monoclonal Antibodies
Research Use Only