RPS3 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A4872-20, A4872-100
Citations, Manuals and SDS Available upon request.
Background: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: S3; uS3; RPS3
GeneID: 6188
Swiss-Prot: P23396
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 27kDa
Observed Molecular Weight: 27kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RPS3 (P23396).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IF/ICC: 1:50 - 1:200
Research Areas: Epigenetics Nuclear Signaling, DNA Damage Repair, RNA Binding, Cell Biology Developmental Biology, Apoptosis
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, HT-29, Mouse liver, Mouse spleen, Mouse pancreas, Rat lung
Cellular Location: Cytoplasm, Mitochondrion Inner Membrane, Nucleus, Peripheral Membrane Protein, Cytoskeleton, NucleolusSpindle
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.