TRIF Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB11719-50, MB11719-100
Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Swiss-Prot: Q8IUC6
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IP,
All Applications: WB: 1/500-1/1000 IP: 1/20
Background: Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines .
Purification and Purity: Affinity Purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IgG
Bioworld Molecular Weight: Calculated MW: 76 kDa; Observed MW: 98 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of TRIF in rat testis lysates using TRIF antibody., Western blot analysis of TRIF in K562, 3T3, Hela lysates using TRIF antibody.
Alternative Name: TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1
Immunogen: Recombinant protein of human TRIF
Conjugate: Unconjugated
Modification: Unmodified