Used to: provide an indication on the general wellness of the organism, identify risks and predisposition to oxidative damage in subjects that are exposed to risk factors or suffering from disease or undergoing treatments.
Evaluates: the free alcohol and hydroperoxyl radicals derived from hydroperoxides present in the sample. The acronym d-ROMs stands for derivates of Reactive Oxygen Metabolites.
Matrix: Serum or Heparinized plasma fresh or frozen
Sector of application: Human and Veterinary
IVD/RUO: For Research Use Only (RUO)
Instrumentation: FREE Systems, manual photometers, multiple analysers, microplate readers
Used for: the prevention of cardiovascular diseases and, specifically, of atherosclerosis damage.
Evaluates: the level of lipid peroxides in circulation and, in particular, of oxidized cholesterol
Matrix: Serum or plasma, fresh or frozen
Sector of application: Human and Veterinary
IVD/RUO: For Research Use Only (RUO)
Instrumentation: FREE Systems, manual photometers
Used to: monitor the correct balance between acidity and alkalinity of blood to prevent tissue damage caused by free radicals.
Evaluates: the metabolic acidity of blood, composed of the set of acids derived by cellular metabolism (especially carbonic acid, lactic acid, pyruvic acid, uric acid and fatty acids)
Matrix: fresh whole blood
Sector of application: Human and Veterinary
IVD/RUO: For Research Use Only (RUO)
Instrumentation: FREE Systems, manual photometers
Used to: evaluate the inflammatory status of the prostate and urinary tract
Evaluates: the peroxidized compounds in urine
Matrix: fresh urine
Sector of application: Human and Veterinary
IVD/RUO: For Research Use Only (RUO)
Instrumentation: FREE Systems, manual photometers
Used to: identify the presence of indican (indoxyl sulfate) in urine caused by an alteration of tryptophan metabolism
Matrix: fresh or frozen urine
Sector of application: Human
IVD/RUO: For Research Use Only (RUO)
Instrumentation: FREE Systems, manual photometers and micro-plate readers
Used for: the treatment of masculine infertility and to identify prostatic inflammatory status
Evaluates: the peroxidation status of sperm
Matrix: sperm liquid, nemasperm, fresh spermatic plasma
Sector of application: Human and Veterinary
IVD/RUO: For Research Use Only (RUO)
Instrumentation: FREE Systems, manual photometers
Used to: assess, through tissues, the oxidative state of organisms in which it is not possible to take biological liquids. Main uses in ecological and veterinary research laboratories.
Evaluates: the peroxidation status of tissue
Matrix: fresh or frozen tissue extracts
Sector of application: Human and Veterinary
IVD/RUO: For Research Use Only (RUO)
Instrumentation: FREE Systems, manual photometers
Used to: evaluate the oxidative state in cell line cultures. Mainly used in research laboratories.
Evaluates: the peroxidation status of cells
Matrix: fresh or frozen cells extracts
Sector of application: Human and Veterinary
IVD/RUO: For Research Use Only (RUO)
Instrumentation: FREE Systems, manual photometers
Used to: measure an inflammatory condition resulting from a bacterial infection of the oral cavity, pharynx or stomach.
Evaluates: the presence of nitric oxide (a radical reactive nitrogen species) in saliva
Matrix: saliva
Sector of application: Human
IVD/RUO: For Research Use Only (RUO)
Qualitative Test: does not require Instrumentation
Antioxidant Status Evaluation
Used to: evaluate the state of antioxidant defenses and/or the effectiveness of specific antioxidant treatments.
Evaluates: the chemically active antioxidant capacity (scavengers) of the plasma barrier. In particular, this includes antioxidants both of exogenous nature (ascorbic acid and tocopherols) and of endogenous nature (uric acid, bilirubin and albumin).
Matrix: Serum or Heparinized plasma, fresh or frozen
Sector of application: Human and Veterinary
IVD/RUO: For Research Use Only (RUO)
Instrumentation: FREE Systems, manual photometers, multiple analysers, microplate readers
Used to: evaluate the state of antioxidant defenses and/or the effectiveness of specific antioxidant treatments. Very useful in the veterinary research field.
Evaluates: the total antioxidant barrier understood as the whole of the chemically active capacity (scavengers) and the plasmatic structural component such as mucopolysaccharides, amino acids and proteins (shock adsorbers).
Matrix: Serum or plasma, fresh or frozen, agri-food extracts
Sector of application: Human, Veterinary and Agri-food
IVD/RUO: For Research Use Only (RUO)
Instrumentation: FREE Systems, manual photometers, microplate readers
Used to: detect conditions lacking thiolic antioxidants and in monitoring the effectiveness of formulations based on active ingredients containing sulfhydryl groups.
Evaluates: the measurement of thiol groups (lipoic acid, glutathione, cysteine) which represent a qualitatively significant component of the plasma antioxidant barrier since they oppose the propagation phase of the radical processes.
Matrix: Serum or plasma fresh
Sector of application: Human and Veterinary
IVD/RUO: For Research Use Only (RUO)
Instrumentation: FREE Systems, manual photometers, microplate readers
Used to: evaluate the state of antioxidant defenses and/or the effectiveness of specific antioxidant treatments. It can be used to monitor the effectiveness of food and/or antioxidant formulations.
Evaluates: the plasma antioxidant barrier with two distinct results: rapid exogenous antioxidants such as Vitamin C and Vitamin E and slow endogenous antioxidants such as uric acid, thiol groups and polyphenols.
Matrix: Serum or Heparinized plasma, fresh
Sector of application: Human, Veterinary and Agri-food
IVD/RUO: For Research Use Only (RUO)
Instrumentation: FREE Systems
In North America, all tests are classified for research use only (RUO).
While all tests of the Panel Carratelli can be used on standard photometers, some of them can be used on microplate readers or automatic analysers. As an alternative it's possible to run the assays with the dedicated FREE systems (FREE Carpe Diem and FREE DUO). As with all the products developed by Mauro Carratelli, the ease of use combined with the reliability of the system is the focus.
Not sure which test to use? Take a look at our quick guide here.
For more information, or on how to include oxidative stress analysis in your research, please do not hesitate to contact us.
