Phospho-AMPKa1-T183 + AMPKa2-T172 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: AP1345-20, AP1345-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Synonyms: AMPKa1/AMPKa2; Phospho-AMPKa1-T183 + AMPKa2-T172
GeneID: 5562/5563
Swiss Prot: Q13131/P54646
Tested Applications: ELISA, WB
Reactivity: Mouse
Calculated Molecular Weight: 64kDa/65kDa/62kDa
Observed Molecular Weight: 62kDa
Immunogen: A synthetic phosphorylated peptide around T183 of human AMPKa1 (NP_006242.5).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Protein phosphorylation
Modifications: Phospho T183
Positive Samples: C2C12+oligomycin
Cellular Location: Apical Plasma Membrane, Cytoplasm, Cytosol, Nuclear speck, Nucleoplasm, Nucleus
Keywords: sc-19128, sc-19126, sc-25792, sc-19131, sc-19129, AMPK, AMPK alpha, AMPK alpha 1, AMPK subunit alpha 1, AMPK1, AMPKa1, PRKAA1, AMPK alpha 2, AMPK subunit alpha 2, AMPK2, AMPKA2, AMPKα2, PRKAA, PRKAA2, protein kinase AMP-activated catalytic subunit alpha 1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase, catalytic alpha-1 chain, ACACA kinase, AMP -activate kinase alpha 1 subunit, AMP-activated protein kinase, catalytic, alpha-1, AMPK subunit alpha-1, HMGCR kinase, acetyl-CoA carboxylase kinase, hydroxymethylglutaryl-CoA reductase kinase, protein kinase, AMP-activated, alpha 1 catalytic subunit, tau-protein kinase PRKAA1, Q13131, AMPKa2, protein kinase AMP-activated catalytic subunit alpha 2, 5'-AMP-activated protein kinase catalytic subunit alpha-2, catalytic alpha-2 chain, AMP-activated protein kinase alpha-2 subunit variant 2, AMP-activated protein kinase alpha-2 subunit variant 3, AMPK subunit alpha-2, AMPK-alpha-2 chain, alpha 2 catalytic subunit, P54646, AMPKa1/AMPKa2, 5562/5563, Q13131/P54646, PRKAA1/PRKAA2, P31749, Phospho-AMPKa1-T183 + AMPKa2-T172
Symbol: PRKAA1/PRKAA2
Category: Phosphorylated Antibodies
Research Use Only