Phospho-ATF-2 (Thr69/71) /ATF-7 (Thr51/53) Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: AP1429-20, AP1429-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene, Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Biomarker of colorectal cancer.
Applications: Phosphorylated Antibodies
Applications: WB, ELISA
Cross-reactivity: Human
Protein Weight: 54kDa/51kDa
Observed Molecular Weight: 75kDa
Immunogen: Synthetic peptide
Species: Human
GeneID: 1386/11016
SWISS: P15336/P17544
Alternate Names: HB16; CREB2; TREB7; CREB-2; CRE-BP1; ATFA; Phospho-ATF-2 (Thr69/71) /ATF-7 (Thr51/53)
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Use Only