Phospho-BRCA1-S988 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: AP0318-20, AP0318-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
Synonyms: IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53; Phospho-BRCA1-S988
GeneID: 672
Swiss Prot: P38398
Tested Applications: ELISA, IHC-P, IF/ICC
Reactivity: Human
Calculated Molecular Weight: 208kDa
Observed Molecular Weight: Refer to figures
Immunogen: A synthetic phosphorylated peptide around S988 of human BRCA1 (NP_009225.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Epigenetics Nuclear Signaling, DNA Damage Repair, Protein phosphorylation, Cancer, Tumor suppressors, ATM Signaling Pathway, Cell Biology Developmental Biology, Cell Cycle, Centrosome, Cell Cycle Control-G2 M DNA Damage Checkpoint, Ubiquitin, Ubiquitin-Proteasome Signaling Pathway
Modifications: Phospho S988
Conjugate: Unconjugated
Cellular Location: Chromosome, Cytoplasm, Cytoplasm, Nucleus,
Keywords: 672, sc-641, sc-642, sc-1021, sc-7867, sc-28234, sc-646, BRCA1, BRCAI, BRCC1, breast cancer 1, early onset, BROVCA1, IRIS, PSCP, RING finger protein 53, RNF53, FANCS, PNCA4, PPP1R53, DNA repair associated, breast cancer type 1 susceptibility protein, BRCA1/BRCA2-containing complex, subunit 1, Fanconi anemia, complementation group S, breast and ovarian cancer susceptibility protein 1, early onset breast cancer 1, protein phosphatase 1, regulatory subunit 53, P38398, DNA Repair Associated, Protein Phosphatase 1, Regulatory Subunit 53, BRCA1/BRCA2-Containing Complex, Subunit 1, Fanconi Anemia, Complementation Group S, Breast Cancer 1, Early Onset, RING Finger Protein 53, Breast And Ovarian Cancer Susceptibility Protein 1, Breast Cancer Type 1 Susceptibility Protein, RING-Type E3 Ubiquitin Transferase BRCA1, Early Onset Breast Cancer 1, EC 2.3.2.27, Phospho-BRCA1-S988, PhosphoBRCA1-S988, Phospho BRCA1-S988, 磷酸化
Symbol: BRCA1
Category: Phosphorylated Antibodies
Research Use Only