Phospho-Cytokeratin 8 (KRT8)-S74 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: AP1299-20, AP1299-100
Citations, Manuals and SDS Available upon request.
Background: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
Synonyms: K8; KO; CK8; CK-8; CYK8; K2C8; CARD2; Phospho-Cytokeratin 8 (KRT8)-S74
GeneID: 3856
Swiss-Prot: P05787
Reactivity: Human
Calculated Molecular Weight: 54kDa
Observed Molecular Weight: 60kDa
Immunogen: A synthetic phosphorylated peptide around S74 of human Cytokeratin 8 (NP_002264.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Cancer, Invasion and Metastasis, Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Cytoskeleton, Intermediate Filaments
Modifications: Phospho S74
Conjugate: Unconjugated
Positive Samples: Hep G2
Cellular Location: Cytoplasm, Nucleus, Nucleus Matrix, Nucleoplasm
Category: Phosphorylated Antibodies
Citations, Manuals and SDS Available upon request.