Phospho-DNMT1-S714 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: AP0021-20, AP0021-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
Synonyms: AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI; Phospho-DNMT1-S714
GeneID: 1786
Swiss Prot: P26358
Tested Applications: ELISA, WB, IF/ICC
Reactivity: Human
Calculated Molecular Weight: 183kDa
Observed Molecular Weight: Refer to Figures
Immunogen: A synthetic phosphorylated peptide around S714 of human DNMT1 (NP_001370.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IF/ICC: 1:50 - 1:200
Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones, Protein phosphorylation
Modifications: Phospho S714
Conjugate: Unconjugated
Cellular Location: Nucleus
Keywords: 1786, sc-10221, sc-10222, sc-10219, sc-20701, AIM, CXXC9, DNA MTase HsaI, DNMT, DNMT1, MCMT, ADCADN, HSN1E, m.HsaI, DNA methyltransferase 1, DNA (cytosine-5)-methyltransferase 1, CXXC-type zinc finger protein 9, DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase HsaI, P26358, DNA Methyltransferase 1, DNA (Cytosine-5-)-Methyltransferase 1, CXXC-Type Zinc Finger Protein 9, DNA Methyltransferase HsaI, M.HsaI, DNA (Cytosine-5)-Methyltransferase 1, EC 2.1.1.37, Dnmt1, Phospho-Dnmt1-S714, PhosphoDnmt1-S714, Phospho Dnmt1-S714, FLJ16293, MGC104992, 磷酸化, Phospho-DNMT1-S714
Symbol: DNMT1
Category: Phosphorylated Antibodies
Research Use Only