Phospho-DRP1-S616 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: AP1353-20, AP1353-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms: DLP1; DRP1; DVLP; EMPF; OPA5; EMPF1; DYMPLE; HDYNIV; Phospho-DRP1-S616
GeneID: 10059
Swiss-Prot: O00429
Reactivity: Human
Calculated Molecular Weight: 82kDa
Observed Molecular Weight: 78-82kDa
Immunogen: A synthetic phosphorylated peptide around S616 of human DNM1L (NP_036192.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Protein phosphorylation, Cancer, Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Endocrine Metabolism, Mitochondrial metabolism, Mitochondrial markers, Neuroscience, Neurodegenerative Diseases, Dopamine Signaling in Parkinson's Disease
Modifications: Phospho S616
Conjugate: Unconjugated
Positive Samples: HeLa
Cellular Location: Cytoplasm, Cytoplasmic Vesicle, Endomembrane System, Golgi Apparatus, Membrane, Mitochondrion Outer Membrane, Peripheral Membrane Protein, Peroxisome, Clathrin-coated Pit, Cytosol, Secretory Vesicle, Synaptic Vesicle Membrane
Category: Phosphorylated Antibodies
Citations, Manuals and SDS Available upon request.