Phospho-eIF4EBP1-T37/T46 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: AP1381-20, AP1381-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Synonyms: BP-1; 4EBP1; 4E-BP1; PHAS-I; Phospho-eIF4EBP1-T37/T46
GeneID: 1978
Swiss Prot: Q13541
Tested Applications: ELISA, WB
Reactivity: Rat
Calculated Molecular Weight: 13kDa
Observed Molecular Weight: 15-20kDa
Immunogen: A synthetic phosphorylated peptide around T37&T46 of human EIF4EBP1.
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:2000 - 1:8000
Research Areas: Epigenetics Nuclear Signaling, Translation Control, Regulation of eIF4 and p70 S6 Kinase, Protein phosphorylation, Signal Transduction, PI3K-Akt Signaling Pathway, mTOR Signaling Pathway, Endocrine Metabolism, AMPK Signaling Pathway, Insulin Receptor Signaling Pathway, Endocrine and metabolic diseases, Diabetes, Obesity, Cardiovascular, Angiogenesis
Modifications: Phospho T37/T46
Conjugate: Unconjugated
Positive Samples: C6
Keywords: sc-6024, sc-6025, sc-6936, 4E BP1, 4EBP1, BP 1, eIF4E binding protein 1, EIF4EBP1, PHAS I, 4E-BP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E binding protein 1, eukaryotic translation initiation factor 4E-binding protein 1, eIF4E-binding protein 1, phosphorylated heat- and acid-stable protein regulated by insulin 1, Q13541, 1978, BP1, MGC4316, PHASI, sc6024, sc 6024, sc6025, sc 6025, sc6936, sc 6936, Phospho-eIF4EBP1-T37/T46
Symbol: EIF4EBP1
Category: Phosphorylated Antibodies
Research Use Only