Phospho-MAP2K3-S189 + MAP2K6-S207 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: AP1112-20, AP1112-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Applications: Phosphorylated Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse
Observed Molecular Weight: 38kDa
Immunogen: Synthetic peptide
Species: Human
GeneID: 5606/5608
SWISS: P46734/P52564
Alternate Names: MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction Protein Phosphorylation Ser / Thr Kinases MAPK PathwayCancer Signal transduction Protein phosphorylation Serine/threonine kinases MAPK pathway
NCBI Alias: MAP2K3/MAP2K6
Research Use Only