Phospho-NF-kB p65/RelA-S536 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: AP1294-20, AP1294-100
Citations, Manuals and SDS Available upon request.
Background: NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
Synonyms: p65; CMCU; NFKB3; AIF3BL3; Phospho-NF-kB p65/RelA-S536
GeneID: 5970
Swiss-Prot: Q04206
Reactivity: Human,Mouse,Rat
Calculated Molecular Weight: 60kDa
Observed Molecular Weight: 65kDa
Immunogen: A synthetic phosphorylated peptide around S536 of human Phospho-NF-kB p65/RelA-S536 (NP_068810.3).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:1000 - 1:5000
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Protein phosphorylation, Cancer, Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Inhibition of Apoptosis, Death Receptor Signaling Pathway, Endocrine Metabolism, Endocrine and metabolic diseases, Obesity, Immunology Inflammation, B Cell Receptor Signaling Pathway, T Cell Receptor Signaling Pathway, Jak-Stat-IL-6 Receptor Signaling Pathway, NF-kB Signaling Pathway, Toll-like Receptor Signaling Pathway, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease, Cardiovascular
Modifications: Phospho S536
Conjugate: Unconjugated
Positive Samples: HeLa, NIH/3T3, C6
Cellular Location: Cytoplasm, Nucleus
Category: Phosphorylated Antibodies
Citations, Manuals and SDS Available upon request.