Coagulation factor III/Tissue Factor Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A1378-20, A1378-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
Synonyms: TF; TFA; CD142; Coagulation factor III/Tissue Factor
GeneID: 2152
Swiss Prot: P13726
Tested Applications: ELISA, WB, IF/ICC
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 33kDa
Observed Molecular Weight: 53kDa/45kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 120-251 of human Coagulation factor III/Tissue Factor (NP_001984.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:100 - 1:500 | IF/ICC: 1:50 - 1:200
Research Areas: Immunology Inflammation, CDs, Cardiovascular, Blood
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: BxPC-3, Mouse brain, Mouse heart
Cellular Location: Membrane, Secreted, Single-pass Type I Membrane Protein,
Keywords: 2152, sc-23596, sc-30201, F3, CD142, TF, TFA, coagulation factor III, tissue factor, coagulation factor III (thromboplastin, tissue factor), P13726, Coagulation Factor III, Tissue Factor, Coagulation Factor III (Thromboplastin, Tissue Factor), Thromboplastin, CD142 Antigen, sc23596, sc 23596, sc30201, sc 30201, Coagulation factor III/Tissue Factor
Symbol: F3
Category: Polyclonal Antibodies
Research Use Only