MAPKBP1 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A12576-20, A12576-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.
Synonyms: JNKBP1; NPHP20; JNKBP-1; MAPKBP1
GeneID: 23005
Swiss Prot: O60336
Tested Applications: ELISA, WB
Reactivity: Human, Mouse
Calculated Molecular Weight: 164kDa
Observed Molecular Weight: 164kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAPKBP1 (NP_001122080.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Signal Transduction, Kinase
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: U-87MG, Mouse liver, Mouse lung
Cellular Location: Cytoplasm, Mitotic Spindle Pole, Nucleolus, Nucleoplasm
Keywords: 23005, sc-164964, sc-164966, MAPKBP1, JNKBP-1, JNKBP1, NPHP20, mitogen-activated protein kinase binding protein 1, mitogen-activated protein kinase-binding protein 1, JNK-binding protein 1, O60336, Mitogen-Activated Protein Kinase Binding Protein 1, JNK-Binding Protein 1, Mitogen-Activated Protein Kinase-Binding Protein 1, Mitogen Activated Protein Kinase Binding Protein 1, KIAA0596, JNKBP 1, MGC138851, MGC138852, sc164964, sc 164964, sc164966, sc 164966, JNK binding protein 1
Symbol: MAPKBP1
Category: Polyclonal Antibodies
Research Use Only