SIRT2 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A12575-20, A12575-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
Synonyms: SIR2; SIR2L; SIR2L2; SIRT2
GeneID: 22933
Swiss Prot: Q8IXJ6
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 43kDa
Observed Molecular Weight: 39kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300-350 of human SIRT2 (NP_036369.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones, Cell Biology Developmental Biology, Apoptosis, Mitochondrial Control of Apoptosis
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Rat brain
Cellular Location: Cell Projection, Chromosome, Cytoplasm, MidBody, Myelin Membrane, Nucleus, Perikaryon, centriole, Centrosome, Cytoskeleton, growth cone, Microtubule Organizing Center, Perinuclear Region, Spindle,
Keywords: 22933, sc-31912, sc-20966, SIR2, SIR2 like protein 2, SIR2L, SIR2L2, SIRT2, sirtuin 2, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-2, SIR2-like protein 2, regulatory protein SIR2 homolog 2, silent information regulator 2, sir2-related protein type 2, sirtuin type 2, Q8IXJ6, Sirtuin 2, Regulatory Protein SIR2 Homolog 2, SIR2-Like Protein 2, Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 2 (S. Cerevisiae), Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 2, NAD-Dependent Protein Deacetylase Sirtuin-2, NAD-Dependent Deacetylase Sirtuin-2, Silent Information Regulator 2, Sir2-Related Protein Type 2, Sirtuin Type 2, EC 3.5.1.-, sc31912, sc 31912, sc20966, sc 20966
Symbol: SIRT2
Category: Polyclonal Antibodies
Research Use Only