SLC6A4 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A23887-20, A23887-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression.
Synonyms: HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR; SLC6A4
GeneID: 6532
Swiss-Prot: P31645
Reactivity: Mouse, Rat
Tested Applications: ELISA, WB
Calculated Molecular Weight: 70kDa
Observed Molecular Weight: 75kDa
Immunogen: Recombinant protein of human SLC6A4.
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Research Areas: Signal Transduction, Endocrine Metabolism, Drug metabolism, Neuroscience, Neurodegenerative Diseases Markers, Other Neurological disorders
Recommended Dilutions: WB: 1:500 - 1:1000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cell Membrane, EndoMembrane System, Endosome Membrane, Multi-pass Membrane Protein
Positive Samples: Mouse brain, Rat brain
Keywords: 6532, SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, solute carrier family 6 member 4, sodium-dependent serotonin transporter, 5-hydroxytryptamine (serotonin) transporter, 5HT transporter, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), P31645, Solute Carrier Family 6 Member 4, Solute Carrier Family 6 (Neurotransmitter Transporter, Serotonin), Member 4, Solute Carrier Family 6 (Neurotransmitter Transporter), 5-Hydroxytryptamine (Serotonin) Transporter, Serotonin Transporter 1, 5HT Transporter, Na+/Cl- Dependent Serotonin Transporter, Sodium-Dependent Serotonin Transporter, Obsessive-Compulsive Disorder 1, HSERT, Serotonin transporter
Symbol: SLC6A4
Category: Polyclonal Antibodies
Research Use Only