A2M Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-66765-60, E-AB-66765-120, E-AB-66765-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: A2M
Target Synonym: A2M; A2MD; CPAMD5; FWP007; S863-7
Research Areas: Cancer, Cell Biology, Cardiovascular
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human
Application: IHC
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P01023
Background: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human A2M (NP_000005.2).
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method: Affinity purification
Dilution: IHC 1:50-1:200
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only