ADAM10 Polyclonal Antibody
Product: 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Sizes: 50µl, 100µl
Catalogue Numbers: BZ16999-50, BZ16999-100
Swiss-Prot: O14672
Host: Rabbit
Reactivity: Human
Applications: WB, IP
All Applications: WB: 1/500-1/1000 IP: 1/20
Background: The ADAM10 prodomain acts as a chaperone that stabilizes mature ADAM protein folding, and prevents target-protein shedding through inhibition of ADAM10 proteinase activity. Mature ADAM10 is the major α-secretase responsible for cleavage of Notch, APP, cadherins, and prion protein. The ADAM10 protein cleaves receptor tyrosine kinases and their associated ligands and displays a wide range of regulatory functions across related signaling pathways.
Purification and Purity: Affinity Purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IgG
Calculated MW: 84 kDa; Observed MW: 90,68 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of ADAM10 in NTERA-2 lysates using ADAM10 antibody.
Alternative Name: CDw156; CD156c; ADAM10; KUZ; MADM
Immunogen: A synthetic peptide of human ADAM10
Conjugate: Unconjugated
Modification: Unmodified