Adenosine Deaminase Monoclonal Antibody
Catalogue Numbers: MB66755-50, MB66755-100
Sizes: 50µl, 100µl
Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Swiss-Prot: P00813
Host: Mouse
Reactivity: Human
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: Adenosine deaminase is an enzyme that is present in most tissues. It exists predominantly as a monomer, although in some tissues it is associated with adenosine deaminase-binding protein. Adenosine deaminase degrades extracellular adenosine, which is toxic for lymphocytes. Adenosine deaminase also effects co-stimulatory signals in T cells via interactions with CD26. Deficiency
of adenosine deaminase has been shown to lead to immunodeficiency diseases such as SCID (severe combined immunodeficiency disease) and has been associated with hereditary hemolytic anemia, a disease in which adenosine deaminase levels are elevated fifty to seventy fold.
Purification and Purity: This antibody is purified through a protein G column.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of Adenosine Deaminase protein.
Extra Notes: Western blot analysis of Adenosine Deaminase expression in CEM (A), Jurkat (B) whole cell lysates.
Bioworld Molecular Weight: ~ 39 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: ADA1; Adenosine deaminase; Adenosine aminohydrolase
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Adenosine Deaminase. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified