ADIPOR1 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90035-50, BS90035-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q96A54(Human) Q91VH1(Mouse) Unigene:104556(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat, zebrafish
Applications: WB, ICC/IF, IHC, FC
All Applications: WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100
Background: Adiponectin is a circulating hormone secreted by adipocytes that improves the metabolism of glucose and lipids, and is expressed at low levels in those with obesity and diabetes. Adiponectin receptors AdipoR1 and AdipoR2, also designated progestin and adipoQ receptor family members I and II, respectively, regulate fatty acid oxidation and the uptake of glucose by adiponectin. Each receptor activates a unique set of signaling molecules including AMPK, p38 MAPK and PPARα. AdipoR1 has a high-affinity for globular adiponectin and low-affinity for full-length adiponectin, while AdipoR2 has an intermediate affinity for both forms. AdipoR1 and AdipoR2 are mainly expressed in liver and muscle. Adiponectin, AdipoR1 and AdipoR2 are all associated with body composition, Insulin sensitivity, and metabolic parameters. Physical training increases circulating adiponectin and mRNA expression of AdipoR1 and AdipoR2 in muscle, which may mediate the improvement of Insulin resistance and the metabolic syndrome in response to exercise.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: ADIPOR1 polyclonal antibody detects endogenous levels of ADIPOR1 protein.
Bioworld Molecular Weight: 43 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of ADIPOR1 on human skeletal muscle lysates using anti-ADIPOR1 antibody at 1/1,000 dilution., ICC staining ADIPOR1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: ADIPOR1, ACDCR1, ADIPO R1, Adiponectin receptor protein 1, ADIPOR 1, Adipor1, ADR1, CGI 45, CGI 45 protein, CGI-45, CGI45, CGI45 protein, FLJ25385, FLJ42464, PAQR1, Progestin and adipoQ receptor family member I, TESBP1A,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified