AGR2 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90038-50, BS90038-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: O95994(Human)
Host: Rabbit
Reactivity: Human
Applications: WB, ICC, IHC, IP, FC
All Applications: WB:1:1,000-1:5,000
ICC:1:100-1:500
IHC:1:50-1:200
FC:1:50-1:100
Background: AGR2 (Anterior Gradient Protein 2), also known as AG2, GOB-4 or HAG-2, is a member of the anterior gradient homolog family. It is the human ortholog of XAG-2, the secreted Xenopus laevis Anterior Gradient protein. In X. laevis, it is involved in cement gland differentiation and neural marker gene expression. AGR2 is a secretory protein encoded by two different AGR2 transcripts. It interacts with LYPD3 and α-dystroglycan (DAG-1). AGR2 is ubiquitously expressed with up-regulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR). AGR2 may serve as a potential therapeutic marker for various cancers.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: AGR2 polyclonal antibody detects endogenous levels of AGR2 protein.
Bioworld Molecular Weight: 17 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of AGR2 on MCF-7 cells lysates using anti-AGR2 antibody at 1/1,000 dilution., ICC staining AGR2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: AG-2, hAG-2, AGR2, AG 2, AG 2 protein, AG-2, AG2, AG2 protein, AGR 2, AGR2, AGR2, Anterior gradient 2 homolog (Xenopus laevis), anterior gradient 2 homolog, Anterior gradient 2, Xenopus, homolog of, Anterior gradient homolog 2, Anterior gradient protein 2 homolog, GOB 4, GOB4, HAG 2, hAG-2, hAG2, HAG2/R, HPC 8, hPC8, PDIA17, Protein disulfide isomerase family A member 17, secreted cement gland homolog, Secreted cement gland protein XAG 2 homolog, Secreted cement gland protein XAG-2 homolog, Secreted cement gland protein XAG2 homolog, XAG 2, XAG2,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified