AKAP 95 (E363) Polyclonal Antibody
Catalogue Numbers: BS1878-50, BS1878-100
Sizes: 50µl, 100µl
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: O43823
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP). AKAP 95, also known as AKAP 8, is a nuclear matrix protein predominantly expressed in liver, heart, pancreas, kidney and skeletal muscle. During mitosis, AKAP 95 is recruited to the chromosomes and plays an essential role in mitotic progression. Characteristic of its family, AKAP 95 participates in PKA signaling through an interaction with the RII regulatory subunit. In addition, AKAP 95 forms a complex with HA95 and HDAC3 and is required for the deacetylation of Histone H3 in mitosis.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: AKAP 95 (E363) pAb detects endogenous levels of AKAP 95 (E363) protein.
Extra Notes: Western blot (WB) analysis of AKAP 95 (E363) pAb at 1:500 dilution
Lane1:EC9706 whole cell lysate(40ug)
Lane2:HepG2 whole cell lysate(40ug)
Lane3:HEK293T whole cell lysate(40ug)
Lane4:AML-12 whole cell lysate(40ug)
Lane5:H9C2 whole cell lysate(40ug)
Bioworld Molecular Weight: ~ 76 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial; Complex I-KFYI; CI-KFYI; NADH-ubiquinone oxidoreductase KFYI subunit; NDUFC1
Immunogen: Synthetic peptide, corresponding Human NDUFC1.
Conjugate: Unconjugated
Modification: Unmodified