ALOXE3 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS71134-50, BS71134-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q9BYJ1
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB IF
All Applications: WB: 1:500~1:2000
IF: 1:50~1:200
Background: This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: ALOXE3 polyclonal antibody detects endogenous levels of ALOXE3 protein.
Bioworld Molecular Weight: ~ 81 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western Blot analysis of extract of various cells, using ALOXE3 antibody.
Alternative Name: ARCI3; E-LOX; eLOX3; eLOX-3;
Immunogen: Recombinant protein of human ALOXE3.
Conjugate: Unconjugated
Modification: Unmodified