Alpha-2-Macroglobulin (A2M) Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS76737-50, BS76737-100
Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P01023
Host: Rabbit
Reactivity: Human
Applications: WB, IHC
All Applications: WB,1:500 - 1:2000 | IHC,1:50 - 1:200
Background: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Unmodification
Extra Notes: Immunohistochemistry of paraffin-embedded human placenta using Alpha-2-Macroglobulin ) antibody at dilution of 1:100 .Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: A2M; A2MD; CPAMD5; FWP007; S863-7
Immunogen: Recombinant fusion protein of human Alpha-2-Macroglobulin (Alpha-2-Macroglobulin (A2M))(NP_000005.2).
Conjugate: Unconjugated
Modification: Unmodified