AMACR Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-40482-60, E-AB-40482-120, E-AB-40482-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: AMACR
Target Synonym: 2 methylacyl CoA racemase; 2-methylacyl-CoA racemase; Alpha methylacyl CoA racemase; Alpha-methylacyl-CoA racemase; Amacr; AMACR; AMACRD; Macr1; RACE; RM
Research Areas: Cell Biology, Metabolism, Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Mouse, Rat
Application: WB, IHC
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: O09174
Background: AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR. It has 3 isoforms produced by alternative splicing. Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4).
Concentration: 1mg/mL
Immunogen: Recombinant Mouse Alpha-methylacyl-CoA racemase protein
Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
Purification Method: Antigen Affinity Purification
Dilution: WB 1:1000-1:3000 IHC 1:100-1:200
Calculated MW: 42 kDa
Observed MW: 40 kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only