Angiotensinogen Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-40478-60, E-AB-40478-120, E-AB-40478-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: Angiotensinogen
Target Synonym: Aangiotensinogen (serpin peptidase inhibitor clade A member 8); AGT; AI265500; Alpha 1 antiproteinase antitrypsin; Ang; Ang I; Ang II; Ang III; AngII; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin-3; Angiotensinogen (PAT); Angiotensinogen; ANGT; ANHU; ANRT; AT-2; AT-II; Des-Asp[1]-angiotensin II; PAT; Pre angiotensinogen; Serine (or cysteine) proteinase inhibitor; Serpin A8; Serpin peptidase inhibitor clade A member 8; SERPINA8
Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Mouse, Rat
Application: WB, IHC
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P11859
Background: Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Concentration: 1mg/mL
Immunogen: Recombinant Mouse Angiotensinogen protein
Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
Purification Method: Antigen Affinity Purification
Dilution: WB 1:2000-1:5000 IHC 1:100-1:300
Calculated MW: 52 kDa
Observed MW: 52 kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only