ANGPTL1 Polyclonal Antibody
Catalogue Numbers: BS67119-50, BS67119-100
Sizes: 50µl, 100µl
Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Swiss-Prot: O95841
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: Angptl1 (angiopoietin-like 1), also known as angioarrestin, ARP1, ANGPT3 or previously known as angiopoietin 3 (ANG3), is a member of the angiopoietinlike family. It is highly expressed in adult tissues, particularly adrenal gland, thyroid, placenta and small intestine. Angptl1 exists as a disulfide-linked
dimer and shares 45.1% identity with Ang-1 and 59% identity with Angptl2.Angptl1 consists of an N-terminus with a coiled-coil domain, potential glycosylation sites and a C-terminus with a fibrinogen-like domain. It is a secreted protein but does not function as a growth factor in endothelial cells. Angptl1 plays a distinct role in the regulation of angiogenesis; inhibiting proliferation,migration, tube formation and endothelial cell adhesion. To exert this inhibitory activity, Angptl1 is speculated to interact with a receptor on endothelial cells. In a wide variety of tumor tissues, Angptl1 expression is down-regulated suggesting that a major function of this protein involves its antiangiogenic properties.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of ANGPTL1 protein.
Extra Notes: Western blot analysis of ANGPTL1 expression in mouse muscle (A), rat muscle (B) whole cell lysates.
Bioworld Molecular Weight: ~ 57 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: ANG3; ANGPT3; ARP1; Angiopoietin-related protein 1; Angiopoietin-3; ANG-3; Angiopoietin-like protein 1
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ANGPTL1. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified