Annexin A1 Monoclonal Antibody
Catalogue Numbers: MB66692-50, MB66692-100
Sizes: 50µl, 100µl
Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Swiss-Prot: P04083
Host: Mouse
Reactivity: Human, Mouse, Rat, Monkey
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: The annexin superfamily consists of 13 calcium or calcium and phospholipid binding proteins with high biological and structural homology. Annexin-1 (ANXA1) is the first characterized member of the annexin family of proteins and is able to bind to cellular membranes in a calcium-dependent manner, promoting membrane fusion and endocytosis. Annexin A1 has anti-inflammatory properties and inhibits phospholipase A2 activity. Annexin A1 can accumulate on internalized vesicles after EGF-stimulated endocytosis and may be required for a late stage in inward vesiculation. Phosphorylation by PKC, EGFR, and Chak1 results in inhibition of annexin A1 function. Annexin A1 has also been identified as one of the 'eat-me' signals on apoptotic cells that are to be recognized and ingested by phagocytes. Annexin A1, as an endogenous anti-inflammatory mediator, has roles in many diverse cellular functions, such as membrane aggregation, inflammation, phagocytosis, proliferation, apoptosis, and tumorigenesis and cancer development.
Purification and Purity: The antibody was purified by immunogen affinity chromatography.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of Annexin A1 protein.
Extra Notes: Western blot analysis of Annexin A1 expression in A549 (A), CHOK1 (B), COS7 (C), C2C12 (D), C6 (E), NIH3T3 (F), Hela (G) whole cell lysates.
Bioworld Molecular Weight: ~ 38 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: ANX1; LPC1; Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35
Immunogen: Purified recombinant human Annexin A1 beta protein fragments expressed in E.coli.
Conjugate: Unconjugated
Modification: Unmodified