DAB2 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS65935-50, BS65935-100
Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Swiss-Prot: P98082
Host: Rabbit
Reactivity: Human, Mouse, Rat,Chicken,Dog, Pig, Cow, Horse, Rabbit,Guinea Pig,
Applications: FCM
All Applications: Flow-Cyt=1ug/Test
Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene
Purification and Purity: affinity purified by Protein A
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: DAB2 Polyclonal Antibody detects endogenous levels of DAB2 protein.
Bioworld Molecular Weight: 82kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: DAB 2; DAB2; DAB2_HUMAN； Differentially expressed protein 2; Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein); disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein); Disabled homolog 2; Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila); Disabled homolog 2 mitogen responsive phosphoprotein; disabled homolog 2 mitogen-responsive phosphoprotein (Drosophila); DOC 2; DOC2; FLJ26626; Mitogen responsive phosphoprotein.
Immunogen: KLH conjugated synthetic peptide derived from human DAB2:31-130/770
Conjugate: Unconjugated
Modification: Unmodified