DCC (F465) Polyclonal Antibody
Catalogue Numbers:BS3232-50, BS3232-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P43146
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: IHC, IF
All Applications: IHC: 1:50~1:200
IF: 1:50~1:200
Background: DCC (deleted in colorectal cancer) was first identified as a candidate tumor suppressor gene based on its absence or reduced expression in the majority of colorectal cancers. Loss of DCC expression was subsequently observed in cancers of the breast, endometrium, brain, pancreas and prostate, as well as in leukemias, neuroblastomas and male germ cell cancers. DCC is a 1447 amino acid transmembrane protein with highest expression in developing brain and neural tube and is suspected to play a role in mediating directional migration in the developing nervous system. Netrin-1, a chemoattractant for commissural axons in the spinal cord, has been identified as a ligand for DCC.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Bioworld Molecular Weight: ~ 158 kDa
Specificity: DCC (F465) polyclonal antibody detects endogenous levels of DCC protein
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: Netrin receptor DCC,Colorectal cancer suppressor,Immunoglobulin superfamily DCC subclass member 1,Tumor suppressor protein DCC,IGDCC1,DCC
Immunogen: Synthetic peptide, corresponding to amino acids 450-500 of Human DCC.
Conjugate: Unconjugated
Modification: Unmodified