Gastrin Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB66765-50, MB66765-100
Product: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.
Swiss-Prot: P01350
Host: Mouse
Reactivity: Human
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: Gastrin, which is normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets, is a hormone whose main function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. Gastrin also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. Gastrin is regulated by epidermal growth factor in both mice and humans. Gastrin is excreted in excess by pancreatic tumors in the ZollingerEllison syndrome. Gastrin maps to human chromosome 17q21.2. GastrinReleasing Peptide (GRP) stimulates the release of gastrin as well as other gastrointestinal hormones, in addition to acting as an autocrine growth factor for certain cell types. High levels of GRP are found in the human lung just after birth and levels decrease thereafter in parallel with the observed disease in a number of pulmonary neuroendocrine cells. GRP is known to promote lung tumorigenesis in model systems and, interestingly, is induced by retinoic acid. GRP is involved in several functions with the hypothalamus, and is thought to play a role in regulating pituitary hormone secretion. GRP maps to human chromosome 18q21.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of Gastrin protein.
Bioworld Molecular Weight: ~ 15 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Gastrin expression in CEM (A) whole cell lysates., ???, ???, ???
GAS; Gastrin
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Gastrin. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified