GBA Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB66790-50, MB66790-100
Product: Mouse IgM. Supplied in crude ascites with 0.01% sodium azide.
Swiss-Prot: P04062
Host: Mouse
Reactivity: Human
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: b-glucosidase is a predominantly liver enzyme which efficiently hydrolyzes b-D-glucoside and b-D-galactoside. Defects in b-glucosidase cause Gaucher disease, an inherited condition distinguished by the accumulation of glucosylceramide within the cells of the reticuloendothelial system. b-glucosidase is used in enzyme replacement treatment aimed at treating Gaucher disease. The absorption of dietary flavonoid glycosides in humans involves a critical deglycosylation step that is mediated by epithelial b-glucosidases.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of GBA protein.
Bioworld Molecular Weight: ~ 57 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of GBA expression in MCF7 (A) whole cell lysates., ???, ???, ???
GC; GLUC; Glucosylceramidase; Acid beta-glucosidase; Alglucerase; Beta-glucocerebrosidase; Beta-GC; D-glucosyl-N-acylsphingosine glucohydrolase; Imiglucerase
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GBA. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified