GNA13 Polyclonal Antibody
Sizes: 50 µl, 100 µl
Catalogue Numbers: BS7833-50, BS7833-100
Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q14344
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IHC, IF/ICC
All Applications: WB,1:500 - 1:2000 | IHC,1:100 - 1:200 | IF/ICC,1:50 - 1:200
Background: Guanine nucleotide-binding proteins (G proteins are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG. GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1 (By similarity. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Polyclonal Antibodies
Bioworld Molecular Weight: 44kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: GNA13; G13
Immunogen: Recombinant fusion protein of human GNA13(NP_006563.2).
Conjugate: Unconjugated
Modification: Unmodified