IL-1 beta Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB66768-50, MB66768-100
Product: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.
Swiss-Prot: P01584
Host: Mouse
Reactivity: Human
Applications: WB
All Applications: WB (1/1000 - 1/2000)
Background: Two forms of interleukin-1, designated IL-1a and IL-1b, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1a and IL-1b bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1b for production of the anti- pathogen IFN-γ. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of IL-1 beta protein.
Bioworld Molecular Weight: ~ 35 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of IL-1 beta expression in 293 cells transfected with IL1B (A) whole cell lysates., ???, ???, ???
IL1F2; Interleukin-1 beta; IL-1 beta; Catabolin
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-1 beta. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified