Phospho-RB-S795 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS79479-50, BS79479-100
Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P06400
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IHC
All Applications: WB,1:500 - 1:2000 | IHC,1:50 - 1:200
Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Phosphorylated
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: OSRC; PPP1R130; RB; p105-Rb; pRb; pp110; RB1; Rb
Immunogen: A synthetic phosphorylated peptide around S795 of human RB(NP_000312.2).
Conjugate: Unconjugated
Modification: Phosphorylated