SOX9 Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB66994-50, MB66994-100
Product: Mouse IgM. Supplied in crude ascites with 0.01% sodium azide.
Swiss-Prot: P48436
Host: Mouse
Reactivity: Human
Applications: WB
All Applications: WB (1/1000 - 1/5000)
Background: Sox9 is a transcription factor with an HMG-box DNA binding domain that has homology to the HMG domain of the mammalian testis-determining factor, SRY . Sox9 regulates several important processes during embryonic development including chondrogenesis, during which it contributes to skeletal formation and digit specification . Sox9 also coordinates with steroidogenic factor-1 to direct Sertoli cell-specific expression of anti-Mullerian hormone during embryogenesis, thereby contributing to male sex determination . In addition, Sox9 is reportedly involved in the maintenance of adult stem cell populations, including multipotent neural stem cells , hair follicle stem cells , and mammary stem cells . Recent interest has focused on the role of Sox9 in tumor biology. For example, research studies have shown that Sox9 expression in lung adenocarcinoma induces a mesenchymal phenotype in tumor cells . Other research studies have shown that YAP1 induced upregulation of Sox9 confers cancer stem cell like properties on esophageal cancer cells . Moreover, Sox9 expression has been linked with several other tumor types including ovarian, prostate, and pancreatic malignancies .
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of SOX9 protein.
Bioworld Molecular Weight: ~ 70 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of SOX9 expression in HepG2 (A) whole cell lysates., ???, ???, ???
Transcription factor SOX-9
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SOX9. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified