14-3-3σ (Phospho Ser186) Rabbit pAb
Sizes: 50µl, 100µl
Catalogue Numbers: RA21469-50, RA21469-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Store at: -20°C/1 year
Recommended Dilutions: WB 1:1000-2000 ELISA 1:5000-20000
Purification Technology:The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Alternative Names: 14-3-3 protein sigma (Epithelial cell marker protein 1;Stratifin)
Background: function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.,function:p53-regulated inhibitor of G2/M progression.,similarity:Belongs to the 14-3-3 family.,subcellular location:May be secreted by a non-classical secretory pathway.,subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.,tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.,
Applications: WB, ELISA
Species Cross-Reactivity: Human, Mouse
Molecular Weight: 130
Protein Molecular Weight (kDa): 130
GeneID (Human): 2810
SWISS: P31947
Source: Rabbit
Immunogen: Synthesized peptide derived from human 14-3-3σ (Phospho Ser186)
Category: Polyclonal
Research Use Only