4E-BP1 (phospho-Thr37/46) Rabbit pAb
Sizes: 50µl, 100µl
Catalogue Numbers: RA21492-50, RA21492-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Store at: -20°C/1 year
Recommended Dilutions: WB 1:1000-2000
Purification Technology:The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Alternative Names: Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)
Background: eukaryotic translation initiation factor 4E binding protein 1(EIF4EBP1) Homo sapiens This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008],
Applications: WB
Species Cross-Reactivity: Human, Mouse, Rat
Molecular Weight: 18
Protein Molecular Weight (kDa): 18
GeneID (Human): 1978
SWISS: Q13541
Source: Rabbit
Immunogen: Synthesized phosho peptide around human 4E-BP1 (Thr37 and 46)
Category: Polyclonal
Research Use Only